Effects Of Oestrogen On Sleep Deprived Induced Stress In Female Wistar Rats Treated With Vitamin C And Vitamin E

Abstract:

Stress is a feeling of mental press and tension on an organism over a period of time. It is known to have affect most population. Oestrogen being a significant compound on the body’s development of an organism and its alteration along with others hormones is reported to have cause negative health effects. This study was designed to investigate the effects of stress on oestrogen level in stress induced female wistar rats. Twenty (20) adult wistar rats were of weight 120-180 kg were randomly divided into four (4) groups of 5 wistar rats each (n=5); Group I: Normal control 1ml/kg Distilled water, Group II: Sleep deprived untreated + distilled water (1ml/kg) only, Group III: Sleep deprived + Vit C (100mg/kg) and Group IV: Sleep deprived + Vit E (100mg/kg). After 7 days, the animals were sacrificed and blood samples collected for biochemical analysis. The result showed that by comparing the untreated to the control, there is statistically significant decrease (p < 0.05) and also comparing the treated with the treated group showed statistically significant increase. Thus, the control of this result showed normal production and release of oestrogen in comparism to both the treated and untreated groups.