Effect Of Tri-Iodothyronine (T3) In Sleep Deprived-Induced Stress In Female Wistar Rats Treated With Ascorbic Acid And Tocopherol

Abstract:

Stress is one of the most fundamental problems spanning through human endeavor, it is considered as an irritating problem that continue to pose threat to the goal of an individual, hence, this research is aimed to study the effect of Tri-iodothyronine (T3) in stress induced female wistar rat treated with ascorbic acid Tocopherol. The stress was induced by sleep deprivation for seven days the rat was sleep deprive for 20hours after which are allowed to rest for 4hours. Total of twenty female wistar rat were grouped into four groups of five rat each (N=5). Group 1 which is the control received 1mg/kg of distilled water, group 2 which is the stress induced and untreated group received 1mg/kg of distilled water, group 3 which is stressed and treated received 100mg/kg of ascorbic acid and group 4 which is stress and treated received 100mg/kg of Tocopherol. The duration of the treatment lasted for 7 days after which they were sacrificed and samples of blood were collected for biochemical analysis, the result shows that there is decrease in T3 level in the stress induced and untreated group, increase in the T3 level in the stress induced and treated with ascorbic acid, decrease in T3 level in the stress induced treated with Tocopherol compare to the control group. In conclusion the findings of the study indicate that Ascorbic acid increases T3 level in sleep deprived stress- induced adult female wistar rat and decrease in T3 level when treated with Tocopherol.