Effect Of Tetraiodothyronine On Stress Induce Adult Female Wistar Rats When Treated With Ascorbic Acid And Tocopherol

Abstract:

Stress affects normal physiological conditions and hence the need for the study which was designed to check the effect of tetraiodothyronine in stress induce adult female wistar rat when treated with vitamin C and E. The animals where divided into four groups of five animals each and treated with vitamin c and e (100mg/kg each) via oral administration as they were deprived of sleep for 20hrs each day, consecutively for a period of 7days. At the end of the experiment animals were sacrificed and sera from blood was obtained for assay of T4. Result obtained from the study showed that, there was a significant increase in level of T4 in sleep untreated group when compared with control. Also, a significant increase in level of T4 was observed for groups treated with vitamin c and e when compared with sleep deprived untreated. In conclusion, vitamin c and e have effect on level of cortisol in sleep deprived female wistar rats.