Effect Of Methanol Fruit Pulp Extract Of Azanza Garckeana (Goron Tula) On Serum Blood Glucose Levels In Adult Wistar Rats

Abstract:

Azanza garckeana commonly known as Goron tula is widely consumed in Northern Nigeria owing to its numerous therapeutic effects. The aim of this study is to determine the effect of methanol fruit pulp of Azanza garckeana on blood glucose level. The acute study was conducted on nine rats which were grouped into three groups with three animals each. Group one served as control and were treated with 10% Tweene 80. Groups two and three were treated orally with 300 mg/kg and 2000 mg/kg of methanol fruit pulp of Azanza garckeana respectively for two weeks. The sub-acute study was conducted on a total of thirty-two (32 n) animals which were divided into four groups each consisting of eight rats. Group one served as the control group and were administered 10% Tweene 80. Group two, three and four were treated with 300 mg/kg, 600 mg/kg and 1200 mg/kg of the extract. The route of administration was oral throughout. The sub-acute study was carried out for twenty-eight (28) days. The blood samples were collected at a weekly interval at the end of week one, two, three and four. The result of the acute study showed that there was no observable changes in both behavioural pattern and physical appearance therefore the extract is considered non-toxic at both high and low doses. The blood glucose result showed no difference between the groups which means that the extract does not have significant ability to cause changes in blood glucose level. In conclusion, methanol fruit pulp extract of Azanza garckeana does not have significant effect on blood glucose level of adult male Wistar rats.